Protein binding pb of antibiotics may affect the ef. According to the free drug theory, only the free drug is able to. Plasma protein binding ppb is a major determinant of the overall pharmacokinetic pk and pharmacodynamic pd profile. Links to pubmed are also available for selected references. Refers to the degree to which drugs attach to proteins in the body. Albumin is the major drug binding protein in the serum, although other proteins, such as. Quantitative structure pharmacokinetics relationships. In a sense, this is not a logical development, because if plasma protein binding of a drug is considered.
The fraction of unbound drug in plasma fu was used as a quantitative measure for plasma protein binding. Since these proteins are large, bound drugs cannot pass out of vascular space thus plasma protein binding has the effect of restricting the distribution of drugs as plasma protein binding increases, the extent of distribution. Pdf protein binding and kinetics of drugs in liver diseases. Protein binding and kinetics of drugs in liver diseases. The mol files of the drugs were retrieved from public databases drugbank 39 and chemical book 40.
Full text full text is available as a scanned copy of the original print version. Binding to plasma proteins plays a major role in drug therapy as this binding provides a depot for many compounds, affects pharmacokinetics pk and pharmacodynamics pd of drugs, and may in. However, for many antileprosy drugs, the actual mechanisms of action are not known but inferred from studies of m. Most of the drugs bind reversibly to various proteins in plasma.
It was transformed to pfu logfu in order to approach nearly normal distribution, and for better interpretability. Drug protein binding an overview sciencedirect topics. The international textbook of leprosy antileprosy drugs section 5 microbiology 3 of action for most of the effective classes of drugs against m. Bickel studies on drug protein binding in pharmacokinetics were restricted to plasma and its proteins for several decades. Only the past ten years have seen an increasing interest in tissue binding. Drug protein binding may vary from 0% eg, lithium to 99% eg, ketorolac, and it is only the unbound drug free drug that is pharmacologically active. Get a printable copy pdf file of the complete article 695k, or click on a page image below to browse page by page.
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